ABNORMALITIES OF MAGNETIC-RESONANCE-IMAGING OF THE CENTRAL-NERVOUS-SYSTEM IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS CORRELATE WITH DISEASE SEVERITY

Forty randomly selected patients with systemic lupus erythematosus (SL E) were studied by clinical and serologic parameters and magnetic reso nance imaging (MRI). Abnormal MRI was found in 15/40 patients (37,5%): all 15 cases showed multiple widespread small-sized areas of increase d signal in T2 in the white matter; in one of these patients MRI also displayed a large area with a reduced signal in T1 and an increased si gnal in T2 involving both the white and the gray matter. Among the 15 patients with abnormal MRI, only 7 had neuropsychiatric symptoms. The presence of MRI changes was highest in patients with organic type symp toms and was associated to the highest disease severity scores. A long -term follow up of asymptomatic patients would be useful to establish whether the application of MRI is appropriate for the assessment of CN S involvement in SLE.