KINETICS OF ELEMENTAL CONTENT CHANGES OF BONE TISSUE OF MICE DURING EVOLUTION UNDER HYPOKINETIC STRESS

Concentration of 13 elements in bone tissue of mice held in tightly sp aced cages for 3 wk, which caused an acute stress reaction, was determ ined by means of neutron activation analysis. Functionally different b one tissues of mice skeletons-the femur, accomplishing both supporting and dynamic functions; the parietal bone, being practically immovable ; and the ectopic bone, newly formed under kidney capsule in the place of syngeneic bone marrow implantation-were analyzed. Similar dynamics of the elemental composition of investigated bones was found: the pro gressive demineralization owing to the loss of Ca, P, Mg, and Fe is ac companied by the compensatory inclusion of Sr in the bone tissues. Ln the ectopic bone, it was not as high. During evolution under hypokinet ic stress, the microelement concentrations (Zn, Cr, Rb, Ru, Br, Co, Sb ) change significantly. Results obtained form the evidence for some sy stem character of osteoporosis at limited mobility.