EFFECT OF ENHANCED BROMIDE INTAKE ON THE CONCENTRATION RATIO I BR IN THE RAT-THYROID GLAND/

Interaction of bromine with iodine was studied in the rat thyroid glan d under the conditions of different bromide intake. Bromine and iodine in the thyroid dry weight were determined by instrumental neutron act ivation analysis (INAA). It was found that with increased bromide inta ke the bromine concentration in the thyroid gland increased with simul taneous decrease in the iodine concentration. The change in the I/Br c oncentration ratio depends on a number of halogen binding positions an d on the bromide supply. The I/Br parameter reacts sensitively to the changes of bromide intake already in the region of low bromine concent ration levels.