CHEMICAL INCOMPATIBILITY BETWEEN PROCAINAMIDE HYDROCHLORIDE AND GLUCOSE FOLLOWING INTRAVENOUS ADMIXTURE

Authors
SIANIPAR A PARKIN JE SUNDERLAND VB
Citation
A. Sianipar et al., CHEMICAL INCOMPATIBILITY BETWEEN PROCAINAMIDE HYDROCHLORIDE AND GLUCOSE FOLLOWING INTRAVENOUS ADMIXTURE, Journal of Pharmacy and Pharmacology, 46(12), 1994, pp. 951-955
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
46
Issue
12
Year of publication
1994
Pages
951 - 955
Database
ISI
SICI code
0022-3573(1994)46:12<951:CIBPHA>2.0.ZU;2-P
Abstract
The chemical reaction between procainamide hydrochloride and glucose f ollowing admixture to glucose infusion has been investigated. Substant ial amounts (10-15% after 10 h at room temperature) of the procainamid e is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by C-13 and H-1 nuclear magnetic resonance spectroscopy .