DEVELOPMENTAL-CHANGES OF SIALYLATION OF SOLUBLE BETA A4 AMYLOID PROTEIN-PRECURSOR DERIVATIVES IN HUMAN CEREBROSPINAL-FLUID/

Authors
SODEYAMA N SAITO F SAITO K MIYATAKE T YANAGISAWA K
Citation
N. Sodeyama et al., DEVELOPMENTAL-CHANGES OF SIALYLATION OF SOLUBLE BETA A4 AMYLOID PROTEIN-PRECURSOR DERIVATIVES IN HUMAN CEREBROSPINAL-FLUID/, Molecular brain research, 27(2), 1994, pp. 320-322
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
27
Issue
2
Year of publication
1994
Pages
320 - 322
Database
ISI
SICI code
0169-328X(1994)27:2<320:DOSOSB>2.0.ZU;2-C
Abstract
Soluble beta/A4 amyloid protein precursor derivatives (APPs) in cerebr ospinal fluid from infants, children, adults and aged individuals were treated with neuraminidase. In the samples from infants, reduction of molecular weight of APPs following neuraminidase treatment was signif icantly less than those from adults or aged individuals. Hyposialylati on of beta/A4 amyloid protein precursor in infants may be relevant to a physiological role of this molecule in the development of the nervou s system.