CORRELATION BETWEEN [I-125] CALMODULIN-BINDING AND LIPID FLUIDITY IN SYNAPTIC PLASMA-MEMBRANES - EFFECTS OF ETHANOL AND OTHER SHORT-CHAIN ALCOHOLS

Authors
IQBAL Z SZE PY
Citation
Z. Iqbal et Py. Sze, CORRELATION BETWEEN [I-125] CALMODULIN-BINDING AND LIPID FLUIDITY IN SYNAPTIC PLASMA-MEMBRANES - EFFECTS OF ETHANOL AND OTHER SHORT-CHAIN ALCOHOLS, Molecular brain research, 27(2), 1994, pp. 333-336
Citations number
31
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
27
Issue
2
Year of publication
1994
Pages
333 - 336
Database
ISI
SICI code
0169-328X(1994)27:2<333:CB[CAL>2.0.ZU;2-O
Abstract
Ethanol inhibits [I-125]calmodulin binding to synaptic plasma membrane s from rat brain, and this inhibition is correlated in a conentration- dependent manner with the increase of membrane fluidity, as determined by diphenylhexatriene fluorescence polarization. Moreover, several sh ort-chain alcohols that increase membrane fluidity are also effective inhibitors-of [I-125]calmodulin binding. These data support the notion that ethanol inhibits calmodulin binding by increasing lipid fluidity of the synaptic membranes.