CYTOCHROME P-450(CAM) MONOOXYGENASE CAN BE REDESIGNED TO CATALYZE THEREGIOSELECTIVE AROMATIC HYDROXYLATION OF DIPHENYLMETHANE

Authors
FOWLER SM ENGLAND PA WESTLAKE ACG ROUCH DR NICKERSON DP BLUNT C BRAYBROOK D WEST S WONG LL FLITSCH SL
Citation
Sm. Fowler et al., CYTOCHROME P-450(CAM) MONOOXYGENASE CAN BE REDESIGNED TO CATALYZE THEREGIOSELECTIVE AROMATIC HYDROXYLATION OF DIPHENYLMETHANE, Journal of the Chemical Society, Chemical Communications, (24), 1994, pp. 2761-2762
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
24
Year of publication
1994
Pages
2761 - 2762
Database
ISI
SICI code
0022-4936(1994):24<2761:CPMCBR>2.0.ZU;2-K
Abstract
A single-site mutant (Y96A) of the monooxygenase cytochrome P-450(cam) was found to bind diphenylmethane 5 and to catalyse its regioselectiv e aromatic hydroxylation to p-hydroxydiphenylmethane 6.