THE INFLUENCE OF FIBROBLASTS ON THE GROWTH OF HUMAN COLORECTAL-CARCINOMA XENOGRAFTS

Authors
HENNIGAN TW ALLENMERSH TG
Citation
Tw. Hennigan et Tg. Allenmersh, THE INFLUENCE OF FIBROBLASTS ON THE GROWTH OF HUMAN COLORECTAL-CARCINOMA XENOGRAFTS, Surgical oncology, 3(5), 1994, pp. 275-277
Citations number
NO
Categorie Soggetti
Oncology,Surgery
Journal title
Surgical oncology → ACNP
ISSN journal
09607404
Volume
3
Issue
5
Year of publication
1994
Pages
275 - 277
Database
ISI
SICI code
0960-7404(1994)3:5<275:TIOFOT>2.0.ZU;2-0
Abstract
Colorectal carcinoma xenografts were grown in nude mice by inoculation with and without fibroblasts. A significantly greater proportion of t umours grew in mice receiving carcinoma cells with fibroblasts (83% co mpared to 52%). Tumour weight and thymidine DNA labelling were not sig nificantly different. Initial development but not subsequent growth of xenografts was enhanced by fibroblasts.