Ka. Freeman et al., THE RELATIONSHIP BETWEEN VESSEL WALL TENSION AND THE MAGNITUDE AND FREQUENCY OF OSCILLATION IN RAT AORTA, Life sciences, 56(6), 1994, pp. 129-134
Citations number
9
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Aortic rings from adult normotensive rats display spontaneous rhythmic
activity that is enhanced by vasoconstricting agents. Graded doses of
norepinephrine as well as combinations of norepinephrine and vasodila
tors produced levels of tension that were inversely related to the mag
nitude of oscillation and directly related to the frequency. A similar
result occurred with KCl stimulation. Oscillations were only slightly
affected by removal of the endothelium. These results, when combined
with other reported studies, suggest that the oscillations in rat aort
a are a manifestation of feedback control that may involve the cyclic
release of one or more agents affecting calcium channels.