THIOPYRIDYL TRIAZINE DERIVATIVES AND THEIR PLATINUM COMPLEXES - A NEWCLASS OF POTENTIAL ANTITUMOR AGENTS

A novel series of thiopyridyl triazine ligands and their metal(II) com plexes have been synthesized. The X-ray structure of the mononuclear c opper(II) complex of the ligand -thiopyridyl-2,4-bis(dimethylamino)-1, 3,5-triazine (L5) has also been determined. The in vitro cytotoxic pot ency against the human colon cancer cell line (HT-29) has been determi ned for the ligands and their platinum complexes. All compounds includ ing their ligands have been found to be highly potent against the HT-2 9 cell line. The ligand 2,4,6-trithiopyridyl-1,3,5-triazine (L2) and i ts platinum complex were found to be 10-30 times more potent than cisp latin.