EFFECTS OF BMY21190, AN INHIBITOR OF CAMP-PHOSPHODIESTERASE, ON INFARCT SIZE AND MYELOPEROXIDASE ACTIVITY IN THE ISCHEMIC MYOCARDIUM OF A CANINE OCCLUSION-REPERFUSION MODEL

This study was performed to assess the effect of BMY21190, an inhibito r of cAMP phosphodiesterase, on infarct size using a canine ischemic m odel that underwent a 90-min occlusion and a 6-hour reperfusion of the left coronary artery. The infarct zone/area at risk of the BMY21 190 group was significantly smaller than that of the vehicle group (36.1 /- 7.8%; 62.4 +/- 4.3 %, respectively; p < 0.05). Myeloperoxidase acti vity, an indicator of neutrophil infiltration, was significantly corre lated to infarct size (r = 0.6893, p < 0.02). Myeloperoxidase activity (0.14 +/- 0.07 U/100 mg tissues) measured in the area at risk from he arts of the BMY21190-treated group was significantly lower than that o f the vehicle-treated tissue (0.40 +/- 0.08 U/100 mg tissue, p < 0.05) . It is suggested that BMY21190 reduces infarct size through the inhib ition of neutrophil infiltration in the canine model.