COMPARATIVE IN-VITRO ACTIVITY OF FLEROXACIN AGAINST 480 NOSOCOMIAL ISOLATES

A total of 480 recent clinical isolates were tested for their suscepti bility to fleroxacin, norfloxacin, ofloxacin, gentamicin, piperacillin , cefoxitin, cefotaxime and imipenem. Fleroxacin showed potent activit y against strains of Enterobacteriaceae, Acinetobacter spp. and gentam icin-sensitive Pseudomonas aeruginosa with MIC90s ranging from 0.06 to 2 mg/l, although the MIC90 for gentamicin-resistant P. aeruginosa str ains was as high as 32 mg/l. The drug exhibited excellent activity aga inst staphylococci, both methicillin-sensitive and resistant. The over all activity of fleroxacin was comparable with that of norfloxacin and ofloxacin and higher than that exhibited by gentamicin and beta-lacta m antibiotics tested.