RETINOPATHY, GLUCOSE, AND INSULIN IN AN ELDERLY POPULATION - THE ROTTERDAM STUDY

We studied the association between retinopathy and glucose metabolism in a population-based study of elderly men and women, Glucose metaboli sm was assessed by serum fructosamine and a nonfasting oral glucose to lerance test, and retinopathy was evaluated by fundus photography, Ret inopathy was present in 296 of 6,191 subjects examined (4.8%; 120 men and 176 women), Serum glucose and fructosamine levels were higher in s ubjects with retinopathy compared with those without (8.4 vs, 6.8 mmol /l and 329.8 vs, 308.5 mu mol/l, respectively, P < 0.001). Two-hour po stload insulin levels and insulin resistance, assessed by the ratio of postload insulin over postload glucose level, did not differ between the two groups, These associations were similar in men and women and i n subjects with and without diabetes and did not change after adjustme nt for body mass index or systolic blood pressure, Within the group of subjects who had retinopathy, serum glucose was significantly associa ted with the number of hemorrhages, These findings suggest that the pr esence and severity of retinopathy are associated with higher serum gl ucose levels, both in subjects with and without diabetes.