AUTOLOGOUS TRANSPLANTATION IN CHRONIC MYELOGENOUS LEUKEMIA - EUROPEANRESULTS

Autologous stem cell transplantation (ASCT) was performed in 95 patien ts with chronic myelogenous leukemia (CML) inchronic phase and their d ata were reported to the European Bone Marrow Transplant Registry. Mos t patients presented bad prognostic factors. The results were analysed by September 1,1993. The actuarial proportion of patients who achieve d a complete hematological response at one year was 87.3 +/- 7.5% (95% CI). The 3-year percentage of major cytogenetic response was 38.6 +/- 13% (95%CI). The actuarial risk of transformation for the evaluable pa tients was 31.5 +/- 14% (95%CI) and the actuarial survival at four yea rs was 83.3 +/- 10% (95%CI). These encouraging results suggest that AS CT by itself could play a role to prolong survival in CML patients.