OLD RATS ARE UNRESPONSIVE TO THE BEHAVIORAL-EFFECTS OF ADRENOCORTICOTROPIN

Authors
POGGIOLI R BENELLI A ARLETTI R VERGONI AV MENOZZI B BERTOLINI A
Citation
R. Poggioli et al., OLD RATS ARE UNRESPONSIVE TO THE BEHAVIORAL-EFFECTS OF ADRENOCORTICOTROPIN, European journal of pharmacology, 271(2-3), 1994, pp. 253-257
Citations number
51
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
271
Issue
2-3
Year of publication
1994
Pages
253 - 257
Database
ISI
SICI code
0014-2999(1994)271:2-3<253:ORAUTT>2.0.ZU;2-T
Abstract
In 28 month-old male rats, the i.c.v. injection of adrenocorticotropin [ACTH-(1-24)] (4 mu g/rat) did not induce the typical behavioral synd rome (excessive grooming, stretching, yawning, penile erections). This indicates that the behavioral effects of melanocortins are age-depend ent, suggesting either an aging-linked impairment of the nervous circu itries involved or a reduction of the number (or affinity, or both) of the brain melanocortin receptors in the elderly.