AMPHETAMINE-LIKE EFFECT OF L-DEPRENYL (SELEGILINE) IN DRUG DISCRIMINATION STUDIES

l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like di scriminative stimulus properties in rats and monkeys. However, these a ctions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic con version to amphetamine products. In view of its weak potency for produ cing amphetamine-like effects and their slow onset, it may not be surp rising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkin son syndrome for more than 20 years with no reported instances of abus e.