Zy. Xu et al., LONG-TERM EFFICACY OF ACTIVE POSTEXPOSURE IMMUNIZATION OF INFANTS FORPREVENTION OF HEPATITIS-B VIRUS-INFECTION, The Journal of infectious diseases, 171(1), 1995, pp. 54-60
Perinatal transmission of hepatitis B virus (HBV) contributes to the h
igh prevalence of chronic infection in China and many other countries.
In a placebo-controlled trial among 166 infants, the 12-month efficac
y of active postexposure prophylaxis to prevent chronic perinatal HBV
infection varied by vaccine (range, 45%-89%). In a 5-year follow-up st
udy, 2 additional infants became chronically infected with HBV, and th
e efficacy of active prophylaxis was estimated to be 38% and 72% for t
he two vaccines at 5 years. In addition, 80% of immunized infants cont
inued to have protective levels of antibody at the end of 5 years. How
ever, among 27 infants who received passive-active immunoprophylaxis w
ith high-dose hepatitis B immune globulin, only 60% (11/19) had protec
tive antibody levels. These data indicate that active postexposure imm
unization initiated soon after birth continues to provide protection d
uring early childhood when there is a high risk of chronic HBV infecti
on.