A practical triple energy window technique (TEW) if proposed, which is
based on using the information in two lower energy windows and one si
ngle calibration, to estimate the scatter within the photopeak window.
The technique is basically a conventional dual-window technique plus
a modification factor, which can partially compensate object-distribut
ion dependent scatters. The modification factor is a function of two l
ower scatter windows of both the calibration phantom and the actual ob
ject. In order to evaluate the technique, a Monte Carlo simulation pro
gram, which simulates the PENN-PET scanner geometry, was used. Differe
nt phantom activity distributions and phantom sizes were tested to sim
ulate brain studies, including uniform and nonuniform distributions. T
he results indicate that the TEW technique works well for a wide range
of activity distributions and object sizes. The comparisons between t
he TEW and dual window techniques show better quantitative accuracy fo
r the TEW, especially for different phantom sizes. The technique is al
so applied to experimental data from a PENN-PET scanner to test its pr
acticality.