CHIRAL LIGANDS CONTAINING HETEROATOMS .12. SYNTHESIS OF OPTICALLY-ACTIVE 2-AMINO-2-(2'-PYRIDYL)-1-ALKANOLS FROM BETA-HYDROXY-ALPHA-AMINO ACIDS

The synthesis of a new class of optically active ligands such as the t itle compounds is presented. All the multistep procedures adopted star t by the conversion of L-serine and L-threonine into the proper 2,2-di methyloxazolidines, followed by transformation of the corresponding ni triles to pyridines. The reaction sequence occurs without loss of enan tiomeric purity and with overall satisfactory yield.