RECURRENCE OF IMMUNOGLOBULIN A-KAPPA CRYSTALLINE DEPOSITION DISEASE AFTER KIDNEY-TRANSPLANTATION

Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopat hic glomerulonephritis due to immunoglobulin A-kappa deposition. Ultra structural studies revealed highly ordered deposits in the capillary l umen, mesangium, and basement membrane. The disease recurred at 2.5 ye ars after a cadaveric kidney transplantation. Pulse steroid therapy wa s repeatedly effective in retarding further progression of renal deter ioration in this patient. (C) 1995 by the National Kidney Foundation, Inc.