Ls. Pais et al., SEPARATION OF 1,1'-BI-2-NAPHTHOL ENANTIOMERS BY CONTINUOUS CHROMATOGRAPHY IN SIMULATED MOVING-BED, Chemical Engineering Science, 52(2), 1997, pp. 245-257
The chromatographic separation of 1,1'-bi-2-naphthol enantiomers with
3,5-dinitrobenzoyl phenylglycine bonded to silica gel stationary phase
s is studied. Continuous chromatography in simulated moving bed (SMB)
is analyzed by modeling, simulation and operation of a SMB pilot unit
Licosep 12-26 from Separex (France). A model for the prediction of the
cyclic steady-state performance of the SMB is developed based on the
analogy with the true moving bed (TMB). The model assumes axial disper
sion flow for the liquid phase, linear driving force (LDF) approximati
on for intraparticle mass transfer rate and takes into account multico
mponent adsorption equilibria. The SMB package allows the simulation o
f the pilot unit. The effect of operating variables (switching time, e
xtract and feed how rates, section length) and number of mass transfer
units on the SMB performance is analyzed. The SMB performance is char
acterized by purity, recovery, solvent consumption and adsorbent produ
ctivity. The package also allows the simulation of the dynamic evoluti
on of internal profiles for the transient operation of a TMB. The oper
ation of the SMB pilot unit was carried out for the separation of race
mic mixtures of bi-naphthol enantiomers. Using a 8-column configuratio
n purities as high as 94.5% of the more retained species in the extrac
t and 98.9% of the less retained species in the raffinate were obtaine
d. Copyright (C) 1996 Elsevier Science Ltd.