Sb. Bhavsar et al., SYNTHESIS OF SUBSTITUTED COUMARINYLOXY TRIAZOLES AND THIADIAZOLES ANDTHEIR ANTIMICROBIAL ACTIVITY, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(1), 1995, pp. 70-74
Hydrazides and thiosemicarbazides of substituted coumarins have been s
ynthesised by condensing substituted carbethoxy coumarins with hydrazi
ne hydrate and aryl isothiocyanates respectively. The thiosemicarbazid
es when cyclised on treatment with NaOH and conc. H2SO4 give triazoles
and thiadiazoles. The synthesised compounds have been tested for thei
r anti-microbial activity against Alternaria brassicicola, Fusarium ud
am, Staphyococcus gram (-ve), Lactobacilus gram (-ve). However none of
them show any significant activity.