SYNTHESIS OF SUBSTITUTED COUMARINYLOXY TRIAZOLES AND THIADIAZOLES ANDTHEIR ANTIMICROBIAL ACTIVITY

Authors
BHAVSAR SB SHINDE DB SHINGARE MS
Citation
Sb. Bhavsar et al., SYNTHESIS OF SUBSTITUTED COUMARINYLOXY TRIAZOLES AND THIADIAZOLES ANDTHEIR ANTIMICROBIAL ACTIVITY, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(1), 1995, pp. 70-74
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
1
Year of publication
1995
Pages
70 - 74
Database
ISI
SICI code
0376-4699(1995)34:1<70:SOSCTA>2.0.ZU;2-2
Abstract
Hydrazides and thiosemicarbazides of substituted coumarins have been s ynthesised by condensing substituted carbethoxy coumarins with hydrazi ne hydrate and aryl isothiocyanates respectively. The thiosemicarbazid es when cyclised on treatment with NaOH and conc. H2SO4 give triazoles and thiadiazoles. The synthesised compounds have been tested for thei r anti-microbial activity against Alternaria brassicicola, Fusarium ud am, Staphyococcus gram (-ve), Lactobacilus gram (-ve). However none of them show any significant activity.