COMPARATIVE-STUDY ON CYTOGENETIC DAMAGE-INDUCED BY HOMO-AZA-STEROIDALESTERS IN HUMAN-LYMPHOCYTES

Authors
MOURELATOS D PAPAGEORGIOU A BOUTIS L CATSOULACOS P
Citation
D. Mourelatos et al., COMPARATIVE-STUDY ON CYTOGENETIC DAMAGE-INDUCED BY HOMO-AZA-STEROIDALESTERS IN HUMAN-LYMPHOCYTES, Mutation research. Section on environmental mutagenesis and related subjects, 334(1), 1995, pp. 19-22
Citations number
15
Categorie Soggetti
Genetics & Heredity","Environmental Sciences
Journal title
Mutation research. Section on environmental mutagenesis and related subjects → ACNP
ISSN journal
01651161
Volume
334
Issue
1
Year of publication
1995
Pages
19 - 22
Database
ISI
SICI code
0165-1161(1995)334:1<19:COCDBH>2.0.ZU;2-M
Abstract
The effect of P[N,N-bis(2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-N-methyl-17 alpha-aza-D-homo-5 alpha-androstan-17-one (co mpound 3) and 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstane (c ompound 2) on sister-chromatid exchange (SCE) frequencies and on human lymphocytes proliferation kinetics was studied. The results are compa red with those of the P[N,N-bis(2-chloroethyl)amino]phenylacetate este rs of 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstan-17-one (com pound 1). All compounds were found to be active in inducing markedly i ncreased SCE rates and cell division delays. A correlation between pot ency for SCE induction, effectiveness in cell division delay and previ ously established antitumour activity of these compounds was observed.