Isopentenyl adenosine derivatives can be found next to the anticodon (
position 37) in tRNA from both the Bacteria and Eucarya domains. These
modified nucleosides improve the efficiency of tRNA in translation, c
an increase and decrease translational fidelity, and make the tRNA les
s codon context sensitive. In bacteria the synthesis of isopentenyl ad
enosine derivatives seems to be linked to iron metabolism and central
metabolic pathways.