Tp. Curran et Pm. Mcenaney, SHORT SYNTHESIS OF BICYCLIC DIPEPTIDES CORRESPONDING TO XXX-L-PRO ANDXXX-D-PRO HAVING CONSTRAINED CIS-PROLINE AMIDES, Tetrahedron letters, 36(2), 1995, pp. 191-194
A short synthesis that generates two isomeric bicyclic dipeptides havi
ng constrained, cis-proline amide bonds has been developed. One of the
se bicyclic dipeptides corresponds to an Xxx-L-Pro dipeptide (17), whi
le the other isomer corresponds to an Xxx-D-Pro dipeptide (18).