THE INTRAMOLECULAR ADDITION OF SILYLATED ALKYNES TO ALDEHYDES - METHODOLOGY FOR THE CONSTRUCTION OF CYCLIC ENEDIYNES AND ITS APPLICATION TODYNEMICIN ANALOGS

Authors
WENDER PA BECKHAM S MOHLER DL
Citation
Pa. Wender et al., THE INTRAMOLECULAR ADDITION OF SILYLATED ALKYNES TO ALDEHYDES - METHODOLOGY FOR THE CONSTRUCTION OF CYCLIC ENEDIYNES AND ITS APPLICATION TODYNEMICIN ANALOGS, Tetrahedron letters, 36(2), 1995, pp. 209-212
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
2
Year of publication
1995
Pages
209 - 212
Database
ISI
SICI code
0040-4039(1995)36:2<209:TIAOSA>2.0.ZU;2-O
Abstract
Upon treatment with CsF, silylated alkynes react intramolecularly with aldehydes or iminium ions to form in one step in the presence of elec trophilic trapping agents the cyclic enediyne ring system of dynemicin , with provision for the incorporation of various DNA recognition elem ents.