STEREOCONTROL OF BETA-LACTAM FORMATION USING MICROWAVE IRRADIATION

Authors
BOSE AK BANIK BK MANHAS MS
Citation
Ak. Bose et al., STEREOCONTROL OF BETA-LACTAM FORMATION USING MICROWAVE IRRADIATION, Tetrahedron letters, 36(2), 1995, pp. 213-216
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
2
Year of publication
1995
Pages
213 - 216
Database
ISI
SICI code
0040-4039(1995)36:2<213:SOBFUM>2.0.ZU;2-Z
Abstract
Formation of beta-lactams by the reaction of an acid chloride, a Schif f base and a tertiary amine seems to involve multiple pathways some of which are very fast at higher temperatures. When beta-lactam formatio n is conducted in open vessels in unmodified domestic microwave ovens, high level irradiation lends to preferential formation of trans beta- lactams in several cases when the Schiff base is derived from an aryl aldehyde rather than glyceraldehyde acetonide.