CHEMOSELECTIVE LIGATION OF MULTIFUNCTIONAL PEPTIDES TO TOPOLOGICAL TEMPLATES VIA THIOETHER FORMATION FOR TASP SYNTHESIS

Covalent attachment of multifunctional peptides to a topological templ ate containing four maleimide functions was achieved via thioether for mation; the resulting TASP (Template Assembled Synthetic Protein) mole cules are obtained in high yield and purity.