Jm. Chen et al., MAGNETIC-RESONANCE-IMAGING AND INTRAOPERATIVE FROZEN-SECTIONS IN INTRATEMPORAL FACIAL SCHWANNOMAS, The American journal of otology, 16(1), 1995, pp. 68-74
Seven cases of intratemporal facial schwannoma were assessed by preope
rative magnetic resonance imaging (MRI) and intraoperative frozen sect
ions to determine tumor boundaries. These results were then analyzed w
ith respect to gross tumor appearance, under the operating microscope,
and final histopathologic diagnosis, with immunostains. Gadolinium-en
hanced MRI was helpful in planning the surgical approach and in defini
ng the extent of tumor involvement relative to the facial nerve. Froze
n sections on the other hand were often unreliable in confirming the c
ompleteness of resection, frequently overestimating tumor infiltration
. Ultimately, tumor-nerve interface, especially in the proximal facial
segments, is best judged by its gross intraoperative appearance under
high magnification, with the aid of MRI. The difficulty in establishi
ng tumor infiltration in the presence of organized neural fibers and a
rtifacts is emphasized. Immunohistochemical assays are essential in th
is regard. Complete tumor removal was achieved in all seven cases, wit
h acceptable functional outcome in those with sufficiently long follow
-up.