Ln. Tran et al., COMBINATION CHEMOTHERAPY AND RADIOTHERAPY FOR A LOCALLY ADVANCED SQUAMOUS-CELL CARCINOMA OF THE URETHRA - A CASE-REPORT, The Journal of urology, 153(2), 1995, pp. 422-423
A 68-year-old patient with advanced stage IVB squamous cell carcinoma
of the urethra was treated successfully by combined radiation therapy
to 5,580 cGy., and chemotherapy with 5-fluorouracil and mitomycin. Dra
matic response in the size of the tumor was noted and on the last day
of treatment there was no definite evidence of persistent disease. No
surgery was performed except for urinary diversion. The patient remain
ed without disease for 5.5 years clinically and pathologically. In thi
s case the combination of radiation therapy and chemotherapy obviated
the need for radical surgery. This clinical behavior is markedly simil
ar to the behavior of anal canal carcinoma when using a similar regime
n. Therefore, further clinical investigation for combined modality tre
atment is warranted.