MATHEMATICAL-MODELING OF THE ENTERIC NERVOUS NETWORK .4. ANALYSIS OF ADRENERGIC TRANSMISSION

Based on the model of the adrenergic neurone proposed earlier, the dyn amics of nerve-pulse transmission after treatment with inhibitors of n euronal uptake and catechol-O-methyltransferase, alpha(1)-adrenoceptor antagonists, changes in the concentration of Ca2+ ions in the externa l medium, the action of tetrodotoxin (TTX) and repetitive stimulation, are analysed. The results of numerical simulation show that: the addi tion of drugs that inhibit neuronal uptake and catechol-O-methyltransf erase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitor y post-synaptic potential (IPSP); treatment with adrenergic antagonist s reduces the amplitude of IPSP; decrease in the concentration of extr acellular Ca2+ ions and application of TTX abolish the post-synaptic r esponse. All these effects are shown to be dose-dependent. The repetit ive stimulation of the neurone reproduces the effects of accumulation and potentiation. Possible applications of the results obtained are di scussed.