NEUROPEPTIDES IN THE HUMAN PENIS - AN IMMUNOHISTOCHEMICAL STUDY

Authors
HAUSERKRONBERGER C HACKER GW GRAF AH MACK D SUNDLER F DIETZE O FRICK J
Citation
C. Hauserkronberger et al., NEUROPEPTIDES IN THE HUMAN PENIS - AN IMMUNOHISTOCHEMICAL STUDY, Journal of andrology, 15(6), 1994, pp. 510-520
Citations number
21
Categorie Soggetti
Andrology
Journal title
Journal of andrology → ACNP
ISSN journal
01963635
Volume
15
Issue
6
Year of publication
1994
Pages
510 - 520
Database
ISI
SICI code
0196-3635(1994)15:6<510:NITHP->2.0.ZU;2-F
Abstract
In the present study, the distribution of neuropeptides in the human p enis is demonstrated by immunohistochemistry (IHC). IHC screening dete cted a complex network of nerve fibers containing vasoactive intestina l polypeptide (VIP), peptide histidine-methionine (PHM), prepro-VIP (1 11-122), neuropeptide Y (NPY), C-Ranking peptide of NPY (C-PON), calci tonin gene-related peptide, substance P, and galanin immunoreactivitie s. Special attention was also given to the recently isolated, VIP-rela ted lizard peptide helospectin, which could also be detected in neuron al elements in the penis. Colocalization studies showed the coexistenc e of VIP, PHM, and partly helospectin, and of NPY with C-PON within ne rve fibers in the cavernous and spongious body, the glans penis, and t he Urethra.