CLONING, SEQUENCE-ANALYSIS AND EXPRESSION OF 2 FORMS OF MESSENGER-RNACODING FOR THE HUMAN BETA(2)-SUBUNIT OF THE GABA(A)-RECEPTOR

Authors
MCKINLEY DD LENNON DJ CARTER DB
Citation
Dd. Mckinley et al., CLONING, SEQUENCE-ANALYSIS AND EXPRESSION OF 2 FORMS OF MESSENGER-RNACODING FOR THE HUMAN BETA(2)-SUBUNIT OF THE GABA(A)-RECEPTOR, Molecular brain research, 28(1), 1995, pp. 175-179
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
28
Issue
1
Year of publication
1995
Pages
175 - 179
Database
ISI
SICI code
0169-328X(1995)28:1<175:CSAEO2>2.0.ZU;2-M
Abstract
Two forms of cDNA coding for the human GABA(A) beta(2) subunit have be en cloned and sequenced. The two sequences differ by a 114 base pair i nsertion. The insert contains a phosphorylation consensus sequence for calmodulin-dependent protein kinase II. Quantitative PCR studies show that h beta(2L) cDNA represents 10-15% of total h beta(2) cDNA in the 10 brain substructures tested. Analysis of human genomic southern blo ts suggests that the two forms might arise by differential splicing.