SYNTHESIS OF ARYL-SUBSTITUTED ALLYLIC AMINES VIA PALLADIUM-CATALYZED COUPLING OF ARYL IODIDES, NONCONJUGATED DIENES, AND AMINES

Authors
LAROCK RC WANG Y LU YD RUSSELL CE
Citation
Rc. Larock et al., SYNTHESIS OF ARYL-SUBSTITUTED ALLYLIC AMINES VIA PALLADIUM-CATALYZED COUPLING OF ARYL IODIDES, NONCONJUGATED DIENES, AND AMINES, Journal of organic chemistry, 59(26), 1994, pp. 8107-8114
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
26
Year of publication
1994
Pages
8107 - 8114
Database
ISI
SICI code
0022-3263(1994)59:26<8107:SOAAAV>2.0.ZU;2-P
Abstract
The palladium-catalyzed coupling of aryl iodides, nonconjugated dienes , and primary and secondary amines provides omega-aryl allylic amines in good yields by a process involving arylpalladium formation and addi tion to the less-substituted C-C double bond of the diene, palladium m igration to form a pi-allylpalladium intermediate, and nucleophilic di splacement of palladium by the amine.