NATURAL AND SYNTHETIC DERIVATIVES OF DISCORHABDIN-C, A CYTOTOXIC PIGMENT FROM THE NEW-ZEALAND SPONGE LATRUNCULIA CF BOCAGEI

Authors
COPP BR FULTON KF PERRY NB BLUNT JW MUNRO MHG
Citation
Br. Copp et al., NATURAL AND SYNTHETIC DERIVATIVES OF DISCORHABDIN-C, A CYTOTOXIC PIGMENT FROM THE NEW-ZEALAND SPONGE LATRUNCULIA CF BOCAGEI, Journal of organic chemistry, 59(26), 1994, pp. 8233-8238
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
26
Year of publication
1994
Pages
8233 - 8238
Database
ISI
SICI code
0022-3263(1994)59:26<8233:NASDOD>2.0.ZU;2-5
Abstract
Modification of the spiro-cyclohexadienone skeleton of discorhabdin C (3) led to a series of derivatives 6-11. The biological properties of this series were evaluated in a wide range of screens for selective cy totoxicity, antifungal, and antimicrobial properties. The structure an d biological properties of a further discorhabdin, discorhabdin E (5), from a New Zealand sponge Latrunculia cf. bocagei are also presented.