V. Calabro et al., POSITIONAL CLONING OF CDNAS FROM THE HUMAN-CHROMOSOME 3P21-22 REGION IDENTIFIES A CLUSTERED ORGANIZATION OF ZINC-FINGER GENES, Human genetics, 95(1), 1995, pp. 18-21
The human 3p21-22 region is frequently involved in karyotype rearrange
ments associated with malignancies. The high frequency of allelic loss
in this region has been associated with virtually all small cell lung
carcinomas and many renal carcinomas. These findings suggest that at
least one tumor-suppressor gene might be located in 3p21-22. We have r
ecently reported the isolation of a 750-kb yeast artificial chromosome
(YAC) contig from 3p21-22. Here, we describe three new genes isolated
from the 3p YAC contig by using a cDNA hybridization selection. Remar
kably, the three new genes encode zinc-finger proteins, indicating the
presence of a cluster of zinc-finger genes in human chromosome 3p21.