POSITIONAL CLONING OF CDNAS FROM THE HUMAN-CHROMOSOME 3P21-22 REGION IDENTIFIES A CLUSTERED ORGANIZATION OF ZINC-FINGER GENES

Citation
V. Calabro et al., POSITIONAL CLONING OF CDNAS FROM THE HUMAN-CHROMOSOME 3P21-22 REGION IDENTIFIES A CLUSTERED ORGANIZATION OF ZINC-FINGER GENES, Human genetics, 95(1), 1995, pp. 18-21
Citations number
22
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
03406717
Volume
95
Issue
1
Year of publication
1995
Pages
18 - 21
Database
ISI
SICI code
0340-6717(1995)95:1<18:PCOCFT>2.0.ZU;2-R
Abstract
The human 3p21-22 region is frequently involved in karyotype rearrange ments associated with malignancies. The high frequency of allelic loss in this region has been associated with virtually all small cell lung carcinomas and many renal carcinomas. These findings suggest that at least one tumor-suppressor gene might be located in 3p21-22. We have r ecently reported the isolation of a 750-kb yeast artificial chromosome (YAC) contig from 3p21-22. Here, we describe three new genes isolated from the 3p YAC contig by using a cDNA hybridization selection. Remar kably, the three new genes encode zinc-finger proteins, indicating the presence of a cluster of zinc-finger genes in human chromosome 3p21.