C. Leonard et al., ARE AXILLARY RECURRENCE AND OVERALL SURVIVAL AFFECTED BY AXILLARY EXTRANODAL TUMOR EXTENSION IN BREAST-CANCER - IMPLICATIONS FOR RADIATION-THERAPY, Journal of clinical oncology, 13(1), 1995, pp. 47-53
Purpose: To determine the overall survival and local recurrence signif
icance of axillary lymph node extranodal rumor extension (ETE) and whe
ther axillary/chest-wall irradiation influenced any of these outcomes.
Materials and Methods: The records of 81 breast cancer patients treat
ed with radical or modified radical mastectomy at a single surgical pr
actice were eligible for study. Thirty-four patients had ETE: 17 with
focal ETE (< 10 x high-power field) and 17 with extensive ETE (> 10 x
high-power field). Results: With a median follow-up duration of 92 mon
ths, only two patients had on axillary recurrence (2%): one had focal
ETE and one hod no ETE. Neither of these patients received axillary ra
diation therapy. Overall survival and recurrence-free survival were si
gnificantly decreased with ETE in patients whether axillary radiation
therapy had been administered or not. Analysis showed that the age of
the patient correlated significantly with extensive ETE (P = .04) and
that the number of positive lymph nodes (less than or equal to three v
> three) correlated significantly with ETE (whether focal or extensiv
e) (P = .0001). A multivariate analysis of extranodal tumor extension
and number of positive lymph nodes showed that ETE was associated with
decreased survival (P = .05), although to a lesser degree than number
of positive lymph nodes (P = .003). Conclusion: These results show th
at ETE is associated with decreased survival and increased recurrence
rotes regardless of the extent of the radiation therapy field. Also, E
TE does not necessarily indicate a significantly increased incidence o
f axillary recurrence. Therefore, axillary irradiation based on this p
athologic finding may not be indicated.