C. Holubarsch et al., FUNCTIONAL-SIGNIFICANCE OF ANGIOTENSIN RECEPTORS IN HUMAN MYOCARDIUM - SIGNIFICANT DIFFERENCES BETWEEN ATRIAL AND VENTRICULAR MYOCARDIUM, European heart journal, 15, 1994, pp. 88-91
We studied the effects of angiotensin (Ang) I and II in a variety of i
solated human cardiac tissues contracting under physiological conditio
ns (37 degrees C, 60 beats.min(-1)). Ang I and II consistently increas
ed the peak developed force of human atrial muscles by 30-40%, an effe
ct that was completely blocked by 10(-6) M saralasine, but not by the
combination of prazosin and propranolol. However, neither Ang I or II
had significant inotropic effects in right and left ventricular human
preparations. We were also able to demonstrate that the positive inotr
opic effect of Ang II in human right atrial tissue is mediated by the
ATI receptor subtype but not the AT(2) receptor subtype.