The effects of caffeine and smoking on cognitive performance, subjecti
ve variables, heart rate, and EEG were assessed in two sessions. In on
e session, subjects received caffeine (2.5 mg/kg bodyweight), while in
the other they received placebo. In both sessions they smoked a cigar
ette (8 cued puffs) having a nicotine yield of 1.2 mg. Caffeine produc
ed an increase in self-reported muscular tension and tended to increas
e anxiety and delta magnitude. Smoking facilitated performance of a pa
per-and-pencil math task and increased heart rate. Smoking also appear
ed to produce cortical activation as indexed by decreased right fronta
l delta, decreased right centro-parietal theta, globally increased alp
ha, and increased centro-occipital/decreased posterior-temporal beta1.
Smoking also increased central/decreased posterior-temporal beta2. Sm
oking and caffeine did not interact for any measure, suggesting that t
he epidemiological link between smoking and coffee drinking may have a
non-pharmacological basis.