MULTISITE CLINICAL-TRIALS IN ALCOHOLISM-TREATMENT RESEARCH - ORGANIZATIONAL, METHODOLOGICAL AND MANAGEMENT ISSUES

Authors
FULLER RK MATTSON ME ALLEN JP RANDALL CL ANTON RF BABOR TF
Citation
Rk. Fuller et al., MULTISITE CLINICAL-TRIALS IN ALCOHOLISM-TREATMENT RESEARCH - ORGANIZATIONAL, METHODOLOGICAL AND MANAGEMENT ISSUES, Journal of studies on alcohol, 1994, pp. 30-37
Citations number
18
Categorie Soggetti
Substance Abuse","Substance Abuse",Psychology
Journal title
Journal of studies on alcohol → ACNP
ISSN journal
0096882X
Year of publication
1994
Supplement
12
Pages
30 - 37
Database
ISI
SICI code
0096-882X(1994):<30:MCIAR->2.0.ZU;2-#
Abstract
Multisite clinical trials have two major advantages over single-site s tudies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population bei ng studied. However, they are more complex to implement than single-si te studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite desig n, management of such studies, and some statistical issues.