Objective: Neuropsychological test data are applied with increasing fr
equency in research studies and clinical practice in psychiatry. This
article addresses three popular assumptions about neuropsychological t
est data and describes the limitations and contributions of neuropsych
ological assessment of patients with psychiatric disorders. Method: Al
l research articles from major journals in psychiatry and clinical psy
chology since 1991 that focused on neuropsychological assessment of ps
ychiatric patients were reviewed. Other journals and earlier studies w
ere reviewed selectively. Results: Neuropsychological test data have m
ade significant contributions to the development of hypotheses about a
bnormal brain structure and function in patients with psychiatric diso
rders, yet many findings from neuropsychological assessments of psychi
atric patients are misinterpreted. The extent to which neuropsychologi
cal test data in psychiatric populations can be interpreted to reflect
abnormalities in brain structure and function is frequently exaggerat
ed, as is the ability of neuropsychological measures to serve as speci
fic cognitive Probes in imaging studies of physiological activation. O
n the other hand, the utility of neuropsychological test batteries as
measures of the patterns of cognitive strength and deficit in individu
als with specific psychiatric disorders is frequently underestimated.
Conclusions: In addition to testing models of regional brain dysfuncti
on in psychiatric disorders, neuropsychological tests can provide rese
archers in psychiatry with an improved understanding of the relation b
etween central cognitive impairments and symptoms and serve to identif
y cognitive Predictors of course of illness, and they may provide a me
thod for discriminating among heterogeneous forms of some psychiatric
disorders: Clinically, neuropsychological test data can be used to dev
elop treatment strategies tailored for an individual's specific cognit
ive strengths and deficits.