ADMINISTRATION OF CALCITRIOL TO A PREGNAN T WOMAN WITH PARTIAL DIGEORGE-SYNDROME

A 23-year-old pregnant woman was known since birth to have partial DiG eorge syndrome with idiopathic hypoparathyroidism and clinically suspe cted thymus hypoplasia. The hypocalcaemia had until recently been trea ted with 1000 IU vitamin D-3 daily. During the 9th week of pregnancy t he serum calcium level was 1.9 mmol/l, the phosphate one 1,58 mmol/l a nd parathormone 5.6 pg/ml. To ensure better control, calcitriol was gi ven (1.25-[OH](2)-vitamin D-3, initially 1 mu g daily and then, from t he 22nd week of pregnancy onward, 1.5 mu g daily), as well as calcium gluconate and lactate (initially 300 mg daily, then 900 mg daily). The serum calcium level at that time was between 2.0 and 2.5 mmol/l. Beca use of toxaemia of pregnancy the patient was hospitalized and confined to bed during the 37th week, whereupon the serum calcium level rose f rom 2.2 to 2.7 mmol/l, but a decrease in calcitriol dosage resulted in a decrease to within normal limits within one day. A girl was deliver ed by section in the 39th week: she had normal serum calcium and phosp hate levels and appeared healthy.