ELECTROPHILIC AMINATION AND AZIDATION OF CHIRAL ALPHA-ALKYL PHOSPHONAMIDES - ASYMMETRIC SYNTHESES OF ALPHA-AMINO ALPHA-ALKYL PHOSPHONIC-ACIDS

Stereoselective electrophilic aminations of chiral non racemic a-alkyl phosphonamides, derived from N,N'-dimethyl (R,R)-1,2-diaminocyclohexa ne, proceed with moderate to excellent enantioselectivities. The produ cts are hydrolyzed and reduced to the corresponding alpha-alkyl alpha- amino phosphonic acids. The sense of asymmetric induction was confirme d by X-ray crystal structure analysis.