A 2ND-GENERATION PHOTOCHEMICALLY ACTIVATABLE DYNEMICIN ANALOG - A CONCISE SYNTHESIS AND DNA CLEAVAGE STUDIES

Authors
WENDER PA BECKHAM S OLEARY JG
Citation
Pa. Wender et al., A 2ND-GENERATION PHOTOCHEMICALLY ACTIVATABLE DYNEMICIN ANALOG - A CONCISE SYNTHESIS AND DNA CLEAVAGE STUDIES, Synthesis, 1994, pp. 1278-1282
Citations number
55
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Year of publication
1994
Pages
1278 - 1282
Database
ISI
SICI code
0039-7881(1994):<1278:A2PADA>2.0.ZU;2-4
Abstract
A scheme for the design of dynemicin analogs and a concise, efficient route for their synthesis are described. A photochemically activatable analog was prepared and shown to undergo cycloaromatizatian upon irra diation with wavelengths greater than 300 nm. The ability of this comp ound to function as a competent DNA cleaving agent is demonstrated.