The amygdalar complex is a medial temporal lobe structure in the brain
which is widely considered to be involved in the neural substrates of
emotion, Selective bilateral damage to the human amygdala is rare, of
fering a unique insight into its functions. There is impairment of soc
ial perception after amygdala damage, with defective recognition of fa
cial expressions of emotion(1-4). Among the basic emotions, the proces
sing of fear and anger has been shown to be disrupted by amygdala dama
ge(1,2,5). Although it remains puzzling why this not found in all case
s(6), the importance of the amygdala in negative emotion, and especial
ly fear, has been confirmed by conditioning(7), memory(8) and positron
emission tomography (PET) experiments(9,10). Central to our understan
ding of these findings is the question of whether the amygdala is invo
lved specifically in the perception of visual signals of emotion emana
ting from the face, or more widely in the perception of emotion in all
sensory modalities(11). We report here a further investigation of one
of these rare cases, a woman (D.R) who has impaired perception of the
intonation patterns that are essential to the perception of vocal aff
ect, despite normal hearing, As is the case for recognition of facial
expressions, it is recognition of fear and anger that is most severely
affected in the auditory domain, This shows that the amygdala's role
in the recognition of certain emotions is not confined to vision, whic
h is consistent with its being involved in the appraisal of danger and
the emotion of fear(12,13).