PREVENTION OF LIVER-TUMOR COLONIZATION BY COMBINED IMMUNOMODULATION AND LIVER LECTIN BLOCKING

The protective effect of combined treatment (immunomodulation with Pro pionibacterium avidum KP-40; liver lectin blocking by D-galactose admi nistration) on the liver colonization of RAW 117-H10 lymphosarcoma was investigated in BALB/c-mice. Both, immunomodulation with P. avidum KP -40 as well as liver lectin blocking by D-galactose treatment signific antly decreased the number of liver tumor colonies in this experimenta l model. However, the combination of P. avidum KP-40 and D-galactose o bviously proved to be superior to each monotherapy since the liver col onization by RAW 117-H 10 lymphosarcoma could be completely inhibited.