THERMAL STUDIES ON POLYMORPHIC STRUCTURES OF IBOPAMIN

The crystal polymorphism of ibopamin has been investigated and the mea surements suggest that ibopamin exists in two polymorphic forms I and II. The polymorphic monotropic transformation has been verified using differential thermal analysis (DTA) connected with thermomicroscopy (H SM), differential scanning calorimetry (DSC), thermogravimetric analys is (TG) and X-ray powder diffractometry (XRD) equipped with a self-con structed heating device. True densities and specific surface areas of the polymorphs have also been determined. The melting points of forms I and II are (134.8 +/- 0.4)-degrees-C and (130.2 +/- 0.5)-degrees-C, respectively.