APPROACHES TOWARD THE SYNTHESIS OF 2,5-DISUBSTITUTED-1,3-THIAZOLIDINES

Synthetic approaches for new 2,5-disubstituted-1,3-thiazolidines are d escribed. Steric and electronic effects of the N-substituent of the th iazolidine ring represent the major parameter in the rearrangement pro cess. The nmr studies demonstrate that N-unsubstituted 2,5-disubstitut ed-1,3-thiazolidines exist as epimeric mixture, while the correspondin g N-acetylated analogues exist as a conformer mixture.