REACTIONS OF 2,3-DIHYDRO-1H-CYCLOHEPTA[B]PYRAZINES WITH ACYL HALIDES

Authors
KAWAMATA Y IMAFUKU K LI DH JIN ZT LI ZH XIAO YW
Citation
Y. Kawamata et al., REACTIONS OF 2,3-DIHYDRO-1H-CYCLOHEPTA[B]PYRAZINES WITH ACYL HALIDES, Journal of heterocyclic chemistry, 31(6), 1994, pp. 1553-1556
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
6
Year of publication
1994
Pages
1553 - 1556
Database
ISI
SICI code
0022-152X(1994)31:6<1553:RO2WAH>2.0.ZU;2-V
Abstract
When 2,3-dihydro-1H-cyclohepta[b]pyrazine (3) was treated with acetyl chloride under the Friedel-Crafts conditions, its pyrazine ring opened to afford 2-[N'-acetyl-(2-aminoethyl)amino]tropone. Reactions with pr opionyl and butyryl chloride also gave similarly ring-opened products. On the other hand, aromatic benzoyl chlorides reacted with compound 3 to afford N-benzoyl-substituted 2,3-dihydro-1H-cyclohepta[b]pyrazines , in addition to ring-opened compounds.