A SIMPLE PROCEDURE FOR THE SYNTHESIS OF TED-SULFANYL)-4-HYDROXY-6-SUBSTITUTED-PYRAN-2-ONES

A series of 3-(substituted sulfanyl)-4-hydroxy-6-substituted-pyran-2-o nes were synthesized for Human immunodeficiency virus-1 protease inhib ition. These compounds were synthesized in a simple and convergent fas hion to allow us a rapid preparation of many structurally diversified analogues. Thus the condensation of trimethylsilyl enol ethers of corr esponding ketones, with 2-(S-substituted)propane-1,3-dioates afforded the corresponding pyrones in 24-70% isolated yields.